In OnePiece, Devil Fruits are considered to be the treasure of the sea. They grant their users incredible powers, but they take away their ability to swim. It is fair to say that eating a devil fruit is the easiest way of gaining insurmountable power without training.
Each devil fruit has a unique ability, and two devil fruits of the same type can't exist at the same time. Once eaten, a devil fruit can only return into circulation if the user dies. So far there have been a handful of One Piece characters who have consumed a devil fruit and died.
Updated on June 13th, 2022, by Suzail Ahmad: One Piece is one of the few anime series that doesn't kill off characters needlessly. Most of the villains that have been defeated in the series so far have survived, which allows Oda to use them later on. However, after the recent chapters, there is a strong possibility that some of the major characters in the Wano Country arc are very likely dead. With that in mind, we have added the devil fruit users, who could have potentially died in the arc.
15 Kurozumi Orochi (Potentially Deceased)
Kurozumi Orochi is one of the main antagonists of the Wano Country arc. He managed to take over the land of Wano while Oden was away. Orochi hated the entire population of Wano, and he only cared about keeping himself happy, so he allowed Kaido to create armament factories almost everywhere.
Orochi possessed the Hebi Hebi no Mi, Model: Yamata No Orochi, which is a mythical zoan type devil fruit. The fruit allows its user to transform into a mythical creature with eight heads. The devil fruit also grants its user all the attributes of a regular zoan type. In the recent chapters, it was revealed that Denjiro beheaded Orochi, so it is very likely that Orochi is dead.
14 Kaido (Potentially Deceased)
At the beginning of the Wano Country arc, Kaido was considered to be indestructible. He had been in countless fights and over the years, he had gained the reputation of being the "Strongest Creature in the World." Kaido was given the Uo Uo no Mi, Model: Seiryu by Big Mom when they were still members of the Rocks Pirates.
The devil fruit is a mythical zoan, which allows its user to transform into a dragon at will. The devil fruit made it almost impossible for any attacks to damage Kaido's skin and also gives him access to a variety of attacks. Luffy managed to defeat Kaido with a huge punch that was strong enough to destroy an entire island. After taking the punch straight to his head, Kaido fell into the magma pit, and shortly afterward there was a huge blast. All the evidence points towards Kaido's death.
13 Kurozumi Kanjuro (Potentially Deceased)
Kanjuro was a loyal retainer of the Kurozumi Clan, and he joined Oden and his Scabbards because he wanted to make sure that the Kurozumi would come back into power. Kanjuro carefully managed to stay under the radar for many years before his secret was found out by Kin'emon.
Kanjuro ate the Fude Fude no Mi, which is a paramecia type devil fruit. The devil fruit enables its user to create ink from their body, and this ink can be used with a painting brush to create images that can turn into lifelike objects. Kanjuro was mortally wounded by Kin'emon, and the fans never saw him again.
12 Big Mom (Potentially Deceased)
Big Mom is one of the two Yonko, who was involved in the Wano Country arc. She followed the Straw Hats to Wano in order to seek revenge for the mess they had caused in the Whole Cake Island arc. Big Mom ate the Soru Soru no Mi, which is among the strongest devil fruits in existence.
The devil fruit allows its user to steal the soul of other people, and then use it to increase their own strength. Big Mom was taken down by Eustass Kid and Trafalgar Law. After her defeat, she fell into the magma pool, where she was joined by Kaido.
11 Whitebeard
Before his death, Whitebeard was hailed as the "Strongest Man Alive." He was one of the Yonko and led the Whitebeard Pirates. Whitebeard's strength made him one of the most feared pirates throughout the world.
​​​​​​He possessed the Gura Gura no Mi, which is a paramecia-type devil fruit. The devil fruit allowed Whitebeard to create quakes that could potentially destroy an island. Whitebeard was killed during the Summit War that took place on Marineford. The devil fruit is currently wielded by Blackbeard.
10 Portgas D. Ace
Portgas D. Ace was the son of the Pirate King, Gol D. Roger. After setting sail, Ace clashed against several notable pirates, which landed him a bounty of 550,000,000 beris. He joined the Whitebeard Pirates and became the Second Division Commander.
Ace ate the Mera Mera no Mi, a logia-type devil fruit. The devil fruit allowed Ace to create and control fire. With its power, he was able to fend off Aokiji's attacks without any problems. Ace was killed by Akainu during the Summit War and currently, the devil fruit is in the possession of Sabo.
9 Kozuki Toki
Toki was the wife of Kozuki Oden. Using the power of the Toki Toki no Mi, she was able to live in multiple time periods. She traveled into the future with her devil fruit's power until she finally met Oden. Together they sailed with the Whitebeard Pirates for a while.
Toki could also send others into the future, which is how she managed to save Kin'emon and company. She was killed during the raid on the Oden Castle. The devil fruit's current whereabouts remain unknown.
8 Absalom
Absalom was introduced during the Thriller Bark arc as a member of Moria's pirate crew. He served as the leader of the Zombie soldiers and generals. He possessed the Suke Suke no Mi, a devil fruit that allowed him to turn invisible.
The devil fruit can also be used to turn other objects invisible. Being a rare devil fruit, the Blackbeard Pirates found Absalom and killed him. The devil fruit was later eaten by Shiryu.
7 Kurozumi Higurashi
Kurozumi Higurashi played a very important role in the history of Wano. She was a major supporter of Kurozumi Orochi and she used everything in her power to ensure that Orochi would become the Shogun after Sukiyaki's death.
Higurashi wielded the Mane Mane no Mi, a paramecia-type devil fruit that allowed her to change her appearance. The devil fruit's power fooled everyone in Wano and thus paved the way for Orochi to become the Shogun. She was killed by Kaido for interrupting his duel with Oden. Currently, the devil fruit belongs to Bon Clay.
6 Monet
Monet was a member of the Donquixote Pirates, sent to serve Caesar at Punk Hazard by Doflamingo. Monet was Caesar's assistant, and she provided Doflamingo with Intel.
She ate the Yuki Yuki no Mi, a logia-type devil fruit. The fruit allowed Monet to create snow at will. The devil fruit can be considered a watered-down version of Aokiji's Hie Hie no Mi. Monet was killed by Caesar, who stabbed her heart thinking that it was Smoker's.
5 Donquixote Rosinante
Donquixote Rosinante was the younger brother of Doflamingo. Unlike his malevolent elder brother, Rosinante was a very kind person. Rosinante was sympathetic towards Trafalgar Law and actually helped him recover from the Amber Lead syndrome.
Rosinante stole the Ope Ope no Mi from Diez Barrels and gave it to Law. Rosinante possessed the Nagi Nagi no Mi, which allowed him to cancel all kinds of noise. He was killed in cold blood by Doflamingo.
4 Carmel
Carmel was a child trafficker who sold orphans to the World Government. She worked with the Underground and was responsible for the sale of many orphans.
She ate the Soru Soru no Mi, an overpowered devil fruit, which allowed her to steal the souls of other people. Carmel mysteriously disappeared a long time ago and her devil fruit is now in the possession of Charlotte Linlin.
3 Smiley
Smiley was the result of Caesar Clown's efforts. After its creation, Caesar fed it the Sara Sara no Mi, Model: Axolotl. The devil fruit granted Smiley sentience and allowed it to turn into an axolotl.
However, after Smiley's death, the devil fruit returned into circulation. The devil fruit's current whereabouts are unknown.
2 Kurozumi Semimaru
Kurozumi Semimaru played a pivotal role in Orochi's rise to the position of the Shogun. Semimaru teamed up with Higurashi, and together they helped Orochi to beat Oden to the Shogunate.
Semimaru possessed the Bari Bari no Mi, which allowed him to create unbreakable barriers. He used his devil fruit ability to stop Oden's attacks from harming Orochi. Years after his death, the devil fruit was eaten by Bartolomeo.
1 Unnamed Doctor
Ope Ope no Mo's ridiculous power separates it from the regular devil fruits. Before Law ate the devil fruit, it belonged to an unnamed doctor. The doctor performed many incredible surgeries during his lifetime.
The devil fruit was highly sought after by the Marines as well as Doflamingo until it eventually fell into Corazon's hands and he fed it to a young Trafalgar Law.