With The Fantastic Four and Patrick Stewart being confirmed in the MCU, it's only a matter of time until the X-Men join in on the action. Although many are excited for Patrick Stewart to join the party, the best way to do the X-Men in the MCU would be to just reboot the entire series, meaning new actors, new stories, and hopefully a new look and feel with most fans already knowing the overall story of the X-Men with past shows and movies. This would seem like a lot of work, but luckily Marvel has something nobody but DC has, and that is a built-in collection of decades of source material.
The X-Men comics began in 1963 with comic legends Stan Lee and Jack Kirby at the helm. The comics would quickly grow into one of the biggest comics in history with Chris Claremont and Jim Lee bringing the book to its peak with X-Men 1 in 1991 being the highest-selling single issue of all time.
After decades of every rendition being mostly the same, the popular team would later get fresh updates with one of comic book's greatest writers of all time Grant Morrison in 2001. It was a much-needed update for the team, and it gave the characters something new to bite onto. But in 2019, the X-Men found itself in a similar place of needing something fresh for the franchise, thusly bringing in Jonathan Hickman.
Famous for his runs with The Fantastic Four and The Avengers, Hickman has made a name for himself in comics, and it would be him and a team of writers that would usher in a new era of X-Men in 2019 starting with Powers of X and House of X. It is because he brought the X-Men to a new era that his run would work as a great base for the MCU X-Men if it were to happen.
Now Hickman's run is a little scattered at times with multiple stories big and small, spanning multiple books going at once. To say the least it can get a little thick at times with many late readers not really knowing where to start. Before going into the issues and benefits of using Hickman's X-Men run, the plot and storylines should be addressed first.
For the most part, Marvel movie fans are not going to have a single idea of what Krakoa is, there's nothing wrong with that, it just means it definitely would need to be addressed and with how much is involved, possibly a pre-introduction MCU film would probably work best so that fans can see these characters alone before they get revealed to the rest of the cinematic universe.
The film would have to mostly focus on the world of Krakoa as this is the biggest part of Hickman's run. Mutants are no longer separated and scared, they are united and have found a home in Krakoa. A new familiar would have to be established for the audience. The villain-or villains for the movie would have to logically introduce audiences to the ideals of X-Men during their conflict and somehow force the X-Men to reveal themselves.
The Children of the Vault, is a group of technologically evolved humans that believe that they should inherit the planet instead of mutants and especially mankind alike to put it short. The film's purpose would have to be to show fans what this new era of X-Men is like and to bring it forward to continue to grow in the MCU.
There are a few logistical issues with introducing the X-Men to the MCU now, especially with the history of discrimination against mutants. But Hickman's run possibly has an answer to that problem. That would yet again be the mutant nation on the island Krakoa. Instead of living with humans, mutants are free to live on the sentient island that has become the safe haven for all mutants.
Perhaps instead of including the discrimination in the past-which would be difficult with no mention of it in the past of the MCU, instead, have the X-Men be introduced through the previously stated conflict with the children of the vault, then lead to other exploration of Krokoa like the mutant crucible, a way for mutants who lost their gifts in the House of M story to get it back, and other political conflicts of having a mutant nation in the world along with humans. Mutants and the X-Men could be mostly in hiding, perhaps a reason from the past that causes Charles Xavier and Magneto to believe that mutants need to go into hiding and to be protected.
But the bonus of filling plot holes isn't the only reason to use Hickman's expansive X-Men universe, his run could bring a new look and attitude to the MCU. In the past, there have been subgroups within mutants with the large overarching battle of groups being Charles Xavier and his school of gifted youngsters vs Magneto and his group of mutants. But what differentiates Hickman's take is Charles, Magneto, and even Apocalypse coming together for the best of all mutant-kind (at least for the first portion of the current X-Men run.)
Fans who've only seen the movies have seen the same conflict more than once, but creating a united group of mutants would be something new and fresh for fans of the films and comics alike. Using the mutant's conflict with the Children of the Vault as a way to get audiences used to the united X-Men and get audiences invested in the new but familiar relationship that drives the run-being Xavier vs Magneto. This would also work in the X-Men being introduced to the characters of the MCU allowing conflicts to develop from the introduction to the rest of the world-maybe X-Men vs The Avengers?
Finally, what Hickman's run would help with is the X-Men should be left alone from the rest of the MCU. They can still be part of the MCU, with other X-Men characters having cameos in other films and vice-versa. But with the sheer amount of mutants and stories within the lore of X-Men, it would be much smarter to keep them mostly isolated from the rest of the MCU to focus on the rest of the X-Universe and Krakoa as much as possible.