The isekai boom in anime and manga has been going on for the past decade or so. There’s just something captivating about characters from one realm traveling into another, be it through time travel like in Inuyasha, magic like in Magic Knight Rayearth, or through a video game like in Sword Art Online.

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Some isekai stories even change the hero in the process, like in Mushoku Tensei: Jobless Reincarnation, and That Time I Got Reincarnated As a Slime. But others, like these anime series and manga, give their heroes new perspectives by swapping their genders as well as their worlds just to add further intrigue.

Updated on May 29, 2024, by David Heath: It's a stressful time to be gender-non-confirming in a world insistent on maintaining a binary that doesn't really hold up to scrutiny. It can be enough to make people wish they could zap off to an isekai like the leads in A Wild Last Boss Appeared and Only Sense Online.

Still, with the increasing range of gender-twisting stories, be they set in other worlds or otherwise, it shows things may get better in the future. This is why this article has been updated with a few more select gender-swapping isekai manga and anime, and the older entries have been rearranged by MAL/Anime-Planet score, and their details tweaked here and there.

22 She Professed Herself Pupil of the Wise Man

MyAnimeList Score: 6.33 (Anime) 7.09 (Manga)

Best Gender-Bender Isekai- She Professed Herself Pupil of the Wise Man
  • Written by Hirotsugu Ryuusen.
  • Illustrated by Dicca Suemitsu.
  • Manga: Available via Seven Seas Entertainment.
  • Anime: Available on Crunchyroll.

Anime adaptations of gender-bender isekai have been thinner on the ground compared to their print equivalents, and their adaptations aren't necessarily the best either. MAL users certainly found the adaptation of She Professed Herself Pupil of the Wise Man less preferable to the manga, which wasn't as popular as the original light novel. But no matter the medium, they all tell the same story.

Kagami made his name in the VR MMO 'Arch Earth Online' as Danblf, one of the game's Nine Great Sages. But after he falls asleep while customizing his character, he wakes up and finds out that (a) Danblf's been turned into a young girl called Mira, and (b) he's become Mira! To prove herself all over again, she proclaims herself to be Danblf's pupil, and goes on a quest to find the 8 other sages.

21 Reborn as the Hero’s Daughter! Time to Become the Hero Once More!

MyAnimeList Score: 6.34

Gender-Bending Isekai- Reborn as the Hero's Daughter
  • Written by Haruka Kaburagi.
  • Illustrated by Amane Kotodera.
  • Available online through fan translations.

Reborn as the Hero's Daughter! Time to Become the Hero Once More (Eiyuu no Musume toshite Umarekawatta Eiyuu wa Futatabi Eiyuu wo Mezasu) isn’t strictly an isekai, as the hero doesn’t end up in a new world. But they do tackle it from a new perspective, as the half-human, half-demon hero Reid loses his life in battle. In the afterlife, a shady goddess says this isn’t the end, and that he will live again.

Once he wakes up, Reid discovers he’s now Nicole, the daughter of two of his old colleagues. Becoming a tiny girl seems like a bad deal, but the goddess had a point. Back when he was Reid, his demonic heritage made it hard for him to overcome other demons and dark forces. Now as Nicole, with her new life's holy heritage and her past life’s combat experience, she has more potential to vanquish evil.

20 When I Reincarnated, I Was the Heroine, and He Was the Hero

MyAnimeList Score: 6.35

Gender Bending Isekai- I Was the Heroine
  • Written and Illustrated by Moto Mizuno.
  • Available online through fan translations.

Moto Mizuno's When I Reincarnated, I Was the Heroine, and He Was the Hero is very similar to Life With an Ordinary GuyWho Reincarnated into a Total Fantasy Knockout, which came out a year prior. The difference is that the two leads were originally high school students rather than salarymen, and the manga began as a webcomic via Mizuno's Twitter account. It made the leap to print via Comic Gardo, where it has yet to receive an official English translation.

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In life, Keito Azumi is an ordinary schoolboy, but after he gets killed in an accident, he ends up as a fantasy heroine instead. Even worse, his best friend Taiga ends up as the main hero, slaying foes and other threats with ease when Keito struggles. It hasn't caught on as well as its more popular rival overall, but its quicker pace and comedy-based shenanigans have earned it a fanbase.

19 Final Girl

MyAnimeList Score: 6.42

final girl manga panel
  • Written and Illustrated by Yō Kokikuji.
  • Available online through fan translations.

The problem with the isekai genre is that it can be predictable. So many stories involve an ordinary person (or even a total outcast) becoming the key to everything in a new world. Sometimes they have to practice being the big hero, but other times they’re already great and just need to convince everyone else. Yō Kokikuji's one-shot strip Final Girl sticks its hero at a distinct disadvantage instead.

In it, a Japanese man has woken up as one of the characters in the slasher flick “18th Day Sacrifice.” Unfortunately, he's been brought back as Summer, the sexy, flirty one who, according to horror movie tropes, usually dies first. But if she lasts until dawn, she’ll break convention and become the “final girl” who makes it out alive. Can she overcome the horror movie convention and make it to sunrise? Or will she be forced to stick to the script?

18 Since I Have Been Reincarnated as the Daughter of a Duke, I, the "Girl Inside," Will Enjoy Being a Girl as Much as I Can!

MyAnimeList Score: 6.48

Gender Bending Isekai Anime Manga- Daughter of a Duke
  • Written by Shachi.
  • Illustrated by Chagen.
  • Available online via fan translations.

With that mouthful of a title, it's no surprise that this is an adaptation of a web novel. Like their light novel counterparts, their titles are almost as long as their synopses. But as it suggests, Since I Have Been Reincarnated as the Daughter of a Duke sees a guy in his twenties get reincarnated as Miranda Mirandiehl, a child in an aristocratic family living in a fantasy world that resembles the 18th century.

For some, going from being a strapping young man to a tiny girl would take a lot of physical and mental adjustment. However, the protagonist was essentially "a girl inside" already, a trans woman who never got to realize it. Now that she's become Miranda, she can live her new life to the fullest and be as girly as she likes. All she has to adjust to is her old-timey world and its use of magic. How hard could it be?

17 This Is Screwed Up, But I Was Reincarnated as a GIRL in Another World!

MyAnimeList Score: 6.58

Gender-Bending Isekai- This Is Screwed Up
  • Written by Ashi.
  • Illustrated by Keyaki Uchiuchi.
  • Available via Seven Seas Entertainment.

All kinds of transition are fair game for this list, but since most isekai involve magic or other phenomena, they tend to use them to shift shapes. Originally starting life as a light novel by Ashi and illustrated by Kaomin, This Is Screwed Up, But I Was Reincarnated as a GIRL in Another World was adapted into a manga by Keyaki Uchiuchi.

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The story follows Ren, a young girl in a fantasy world who is about to be enslaved by a corrupt merchant when she begins to have visions. She was able to recall living on a world called Earth, where she worked as a research scientist, and was a man. With her old science skills and her new magic knowledge, she breaks free and makes a name for herself in this new world.

16 Fake Saint of the Year: You Wanted the Perfect Saint? Too Bad!

MyAnimeList Score: 6.61

Best Gender-Bender Isekai- Fake Saint of the Year
  • Written by Kabedondaikou.
  • Illustrated by Ekakibit.
  • Available online via fan translations.

There's been a rich supply of manga about people getting pulled into their otome/dating games, and not always as the lead. Thanks to strips like My Next Life as a Villainess: All Routes Lead to Doom, they often end up as a baddy, and either have trouble being mean or become a roaring success at it. Fake Saint of the Year sounds like it's going for the latter, but it's the former.

Fudo Niito, an unemployed layabout (his name is a pun meaning "idle NEET"), was having fun playing his favorite dating game when he fell asleep one night. When he woke up, he found he had become Elize, the game's "fake saint" villain. Usually, she'd torment the heroine, Eliza, and try to keep her from being with the hero, Verner. Unwilling to harm a hair on Eliza's head, Fudo-Elize decides to help her get with Verner instead, while trying to be a genuine saint in the process.

15 Revival Game of Wandering Reincarnations

MyAnimeList Score: 6.64

Gender Bending Isekai- Revival Game
  • Written by Kenji Saitou.
  • Illustrated by Haruto Hino.
  • Available online via fan translations.

Sometimes, no matter how much good a person does, bad things will still happen to them. It's just how life is. Manatsu Asai from Revival Game of Wandering Reincarnations learns this the hard way when his marriage proposal gets rejected. Then, all of a sudden, he's chased down by a Skull Knight who tries to kill him. A swordswoman tries to save him, but he ends up getting killed while trying to save her. He hopes to be reborn into a better world, and kind of gets his wish granted.

He wakes up in the new world as the swordswoman he just saved. She learns she has some special powers and abilities on her side too, like being able to revive instantly on death. But how did she see her new form in the old world with the Skull Knight? Was that a sign of things to come? And if she can't die, was her old self's sacrifice all for nothing? Only the manga has the answer, which gives readers a Dark Souls-like tale with a yuri comedy twist.

14 Herscherik: Heroic Tale of the Reincarnated Prince

MyAnimeList: 6.84

Gender-Bending Isekai- Herscherik R
  • Written by Nobiru Kusunoki.
  • Illustrated by Yuyu Yuzuki.
  • Available online through fan translations.

For one reason or another, many gender-swapping stories tend to go from male to female. It's rare to find a female-to-male change in the media in general, let alone in isekai. Luckily, Herscherik R: Heroic Tale of the Reincarnated Prince manages to feature FtM in another world, as it all starts when office lady Ryōko Hayakawa gets killed in a traffic accident the day before her 35th birthday.

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She finds herself reborn in a fantasy world as Prince Herscherik, a young boy living a high life in the royal court. However, he can't relax while his family's corrupt regime hurts the kingdom's people. He aims to use his old admin skills with the Prince's privileges to change things for the better. However, if he thinks some members of the court will let him get away with it, he's in for a rude awakening.

13 I Am Alice: Body Swap in Wonderland

MyAnimeList Score: 6.90

Gender Bending Isekai Anime Manga- I Am Alice
  • Written & Illustrated by Ayumi Kanō.
  • Available via Seven Seas Entertainment.

Lewis Carroll's Alice's Adventures in Wonderland is one of the oldest and most famous isekai/portal fantasy stories. It sees the titular Alice follow a white rabbit down a hole and into a fantasy land that doesn't make sense. Grinning, creepy cats, tyrannical card-based royalty, a crazy milliner, and his hare, it's a mind-bending tale. Alongside its sequel, Alice Through the Looking Glass, they've been a staple of children's books for over a century.

Makoto picks it out to read to his little sister in I Am Alice: Body Swap in Wonderland. But in a strange process, he ends up being pulled into the book, where he ends up in Alice's body, and Alice ends up in his body in the real world. The only way Makoto can undo this is by heading to Heart's Castle and fighting the King of Hearts. Though being Wonderland, the journey there is bound to be indirect and strange.

12 Thank You, Isekai!

MyAnimeList Score: 7.06

Best Gender-Bender Isekai- Thank You, Isekai
  • Written by Azuki Arai.
  • Illustrated by Zianazu.
  • Available via Comikey.

If readers liked Life With an Ordinary GuyWho Reincarnated into a Total Fantasy Knockout but fancied it with more bromance than romance (or perhaps woman-ce to be more accurate?), they may prefer Thank You, Isekai! Originally appearing in MangaONE, the strip followed two 30-something otaku called Chiba and Sheina, who get on pretty well after meeting at their high school reunion.

It's the only luck they have, as they end up suffering one misfortune after another which leads to their death. But when fate closes a door, it opens a window, and that window leads to a fantasy world where they've both been reincarnated as cute women. The story goes on to follow their new lives through all their ups and downs, which can give readers tonal whiplash as life in a fantasy realm isn't all sunshine and roses.

11 Did I Seriously Just Get Reincarnated as My Gag Character?!

MyAnimeList Score: 7.07

Gender Bending Isekai Anime Manga- Did I Seriously Just Get Reincarnated as My Gag Character
  • Written by Kanade Otonashi.
  • Illustrated by Kamuragi Amano.
  • Available via J-Novel Club.

Originally based on Otonashi's light novel with azutarou, Did I Seriously Just Get Reincarnated as My Gag Character does what it says on the tin. It starts with Tōru, a jaded university student who only feels alive when he plays the VR MMORPG 'Real World Online'. He's been playing the game ever since he was young, when he made a sexy babe character as a joke before making his main character.

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Things take a turn when he gets hit and killed by a bus and reincarnated into the game. But not as his main. He becomes Nacht, the aforementioned babe. She's a dragon princess who's anything but optimized for surviving in a fantasy world. However, as she discovers more creative ways to play the game, she might be more capable of getting by than her raw stats let on.

10 The Old Man Reincarnated as a Villainess

MyAnimeList Score: 7.13

Gender Bending Isekai Anime Manga- The Old Man Reincarnated as a Villainess
  • Written & Illustrated by Michirō Ueyama.
  • Available online through fan translations.

Nowadays, the distance between an isekai tale and a villainess one is only a short hop. There's something about a mean girl that just adds that little bit extra to a fantasy world, or so the reasoning goes. It certainly worked for The Old Man Reincarnated as a Villainess (Akuyaku Reijō Tensei Ojisan in Japanese), as creator Ueyama announced in January that his work would be getting an anime adaptation soon.

It'll take a while for it to be completed and released, so fans can catch up with the original manga. It starts off simply enough, with 52-year-old civil servant Kenzaburō having his daily routine interfered by a traffic accident. When he wakes up, he finds himself in the body of Grace Auvergne, the villainess in his daughter's otome game. He tries to fulfil her mean girl role, but his mild manners and knowledge from his old life make Grace a nicer, more refined figure than the other characters are used to.

9 Only Sense Online

MyAnimeList Score: 7.13

Gender-Bending Isekai- Only Sense Online
  • Written by Zachou Aloha
  • Illustrated by Un Hanikura
  • Available online through fan translations.

Adapted from Zachou Aloha and Yukisan's original light novel, Only Sense Online's manga is a gender-twisting take on a Sword Art Online-esque premise. The titular video game is a VR MMORPG that’s so realistic that it's a whole new world unto itself. Once players have created their avatars, and chosen the right skill set or "Senses," they can play and roam the land to their heart's content.

Yun gets pressured into playing the game by his big sisters, but he’s a novice with bad luck. He has the worst “Senses” and equipment in the game, and the game misreads his stats and turns his in-world avatar into a girl. However, Yun’s new feminine figure finds her calling as a support class and develops tactics that could change how the game is played entirely. What looks 'bad' on paper could make her OP after all.

8 Life with an Ordinary Guy Who Reincarnated into a Total Fantasy Knockout!

MyAnimeList Score: 7.14 (Anime), 7.50 (Manga)

Gender-Bending Isekai- Fabiniku
  • Written by Yū Tsurusaki.
  • Illustrated by Shin Ikezawa.
  • Manga: Available via Seven Seas Entertainment.
  • Anime: Available on Crunchyroll.

Still, it’s hard to beat the traditional isekai formula. Life with an Ordinary Guy Who Reincarnated into a Total Fantasy Knockout went from appearing in Cycomics magazines to reaching audiences worldwide via Seven Seas Entertainment before getting animated in 2021 by OLM. It still stands out from the rest by showing what happens to a friendship when the line between genders is crossed. In other words, can a bromance become a romance?

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Tachibana is having trouble finding a girlfriend because he's constantly overshadowed by his cooler, more handsome friend Jingūji. Frustrated, Tachibana wishes he himself was an irresistible woman. The Goddess of Love grants his wish by taking the two to a fantasy world, and turning Tachibana into its prettiest woman. She tasks Jingūji and Tachibana with defeating its demon lord, but the real challenge will be fighting their growing feelings for each other, as they begin to see each other in new lights.

7 El Hazard: The Magnificent World

MyAnimeList Score: 7.26

Gender-Bending Isekai- El Hazard The Magnificent World
  • Directed by Hiroki Hayashi.
  • Produced by AIC and Pioneer LDC.
  • Available on Crunchyroll.

There are many “portal fantasy” stories, both East and West, that predate the term “isekai”. Yet the El Hazard OVA series may be one of the earliest ones to combine that with some gender twisting. Released in 1995, the series saw high schoolers Makoto, Katsuhiko, Nanami, and their teacher Masamichi get transported to El Hazard, a fantasy world where humans are at war with insectoid-like creatures called the Bugrom.

Makoto and Masamichi come across Rune, princess of Roshtaria, looking for her missing sister Fatora. She’s needed to power a superweapon known as the Eye of God, which might be able to send Makoto and the others back home. The trail on Fatora goes cold, but Makoto does look a lot like her. So, he reluctantly dresses up as Fatora to learn more about tech and El Hazard's gods. It works out surprisingly well for him too.

6 A Wild Last Boss Appeared!

MyAnimeList Score: 7.41

Gender-Bending Isekai- A Wild Last Boss Appeared
  • Written by Firehead.
  • Illustrated by Tsubasa Hazuki.
  • Available online through fan translations.

Most of these stories started off as light novels, but that was just the second stage in A Wild Last Boss Appeared’s life. It was originally a web novel by Firehead, which then became a light novel with illustrations by YahaKo. The manga version was drawn by Tsubasa Hazuki, who also illustrated the Sword Art Online spin-offs Fairy Dance and Mother’s Rosario. As such, the manga's premise is familiar ground for them.

In the video game Exgate Online, Ruphas Maphaal used to rule Midgard with an iron fist until its heroes brought her down once and for all. However, one of Exgate’s players gets reborn inside the game's world as the revived Ruphas, 200 years after her defeat. To figure out how and why he ended up in her body of all places, the player has to make friends and rebuild Ruphas' reputation, lest he ends up getting killed off again.

5 When I Reincarnated, I Was a Princess. So I'm Aiming to Become the Ultimate Sorceress

Anime-Planet Score: 3.74/5 Stars

Gender Bending Isekai- Ultimate Sorceress
  • Written and Illustrated by Akira.
  • Available online via fan translations.

Arguably, the real fantasy of gender-switching stories is being able to live as a woman in worlds with little-to-no sexism. They're not always in a great situation, but when they want to embark on an adventure, there's rarely an authority figure coming in to insist they make sandwiches instead. So, when Ikuto dies and comes back as Princess Isabella in When I Reincarnated, I Was a Princess. So I'm Aiming to Become the Ultimate Sorceress, her heroic ambitions are cut short.

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Her new world's customs say sorcery is too dangerous for her, and that she should devote herself to her future man instead. So, she disguises herself as her old male persona in order to learn magic and become the best sorcerer in the world. Better known by its Japanese title (Tensei Shitara Hime Datta node Dansou Joshi Kiwamete Saikyou Mahoutsukai Mezasu wa), it's perhaps one of the few manga where the lead swaps genders, then has to swap back to achieve her goals.

4 Makai Yōjo ni Tensei-shita Ojisan wa Heiwa no Tame ni Naritai

Anime Planet Score: 3.85/5 Stars

Gender Bending Isekai Anime Manga- Makai Yojo
  • Written & Illustrated by Kyō Kaisei.
  • Available online via fan translations.

Some titles have official releases, or at least standard English titles, while others will only turn up in search engines if people use their original Japanese names. Hence, why any curious readers of this title will have to look up Makai Youjo ni Tensei-shita Ojisan wa Heiwa no Tame ni Naritai instead of 'The Old Man Who Reincarnated as a Demon Girl For The Sake of Peace'. Or something similarly snappy like that.

Laid off from his job at an abusive company, a middle-aged man is down in the dumps when he comes across a magic stone. It sends him off to another world where he becomes Hiyo, the youngest daughter of a demon lord. She tries to make a fresh start with her old knowledge and new magic powers, but the land is wracked by a battle for succession to her father's throne. Hiyo defies her family and joins forces with the hero Ernest to bring peace to the land by any means necessary.

3 Yakuza Reincarnation

MyAnimeList Score: 7.50

Gender-Bending Isekai- Yakuza Reincarnation
  • Written by Takeshi Natsuhara and Hiroki Miyashita.
  • Illustrated by Hiroki Miyashita.
  • Available via Seven Seas Entertainment.

Despite sounding like a direct-to-video action flick, Yakuza Reincarnation (aka Ninkyo Tensei: Isekai no Yakuza Hime) for Sunday Gene-X isn't as straightforward as a bout between cops and robbers. It's about what happens when medieval manners meets yakuza-style 'chivalry', which starts when Ryumatsu Nagamasa, an elderly yakuza member, is ambushed and killed by his younger rivals while defending his turf.

Instead of dying, he wakes up in a new world as its princess, Sanaria Lundberg. While he lacks the regal refinement of a royal, he retains his back tattoo and his old strength. With this power, Sanaria (or "Ryu" to her friends) may be the hero this fantasy realm needs, if they can adjust to her new yakuza-based way of doing things. Turns out honor and duty can be more brusque than her new court is used to.