Any anime series would be incomplete without the inclusion of a villain. The main protagonist's job would be too easy, and it would cause a massive disappointment if the hero just waltzed through the story. So, it is necessary to have a villain in the series.

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Often in anime, the good guys team up to defeat a villain, who is stronger than them, but it is rare for villains to swallow their egos to form a duo with each other. When the villains do form a duo, it is nothing short of a spectacle, and it provides a great deal of excitement. But, which evil anime duos send chills down the spine of the viewers?

7 Jessie And James From Pokemon

Pokemon Jessie and James from Team Rocket

Jessie and James are a well-known villain duo from Pokemon. The two of them are employed by Team Rocket, and they are always trying to get their hands on unique Pokemon in order to please their boss. Most of the time, they don't succeed in their attempts to capture Pokemon.

However, their failures do not demoralize them instead, it only adds to their desire of getting a special Pokemon. Jessie and James are interested in Ash's Pikachu, and they always try to get their hands on him. While they might not be extremely evil, they do work for an organization that mistreats Pokemon, and they try to separate a young trainer from his most beloved Pokemon.

6 Hol Horse And J. Geil From JoJo's Bizarre Adventure

JoJo's Bizarre Adventure Hol Horse and J Geil

They are minor villains who were introduced in StardustCrusaders. Both of them were sent by DIO to prevent the Joestar group from reaching their destination. While Hol Horse had a fairly powerful Stand, he was not courageous, and he would run away at the first sight of danger.

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On the other hand, J. Geil was a purely evil character, who was responsible for the killing of many innocent people including Polnareff's sister. The two of them had decent teamwork, but ultimately they were defeated by the Joestar group.

5 Gyutaro And Daki From Demon Slayer

Gyutaro and Daki from Demon Slayer

The brother-sister duo were the main antagonists of the Entertainment District arc. Together they were a part of the Upper-Rank Six, however, Gyutaro was vastly superior to Daki in terms of strength. But, that didn't stop Daki from being a hateful, arrogant demon.

She was responsible for killing and eating several people, and she would even hit small kids. Gyutaro hated everyone, and he proved to be more than a match for Tengen Uzui. The demon sliced off one of Tengen's arms and injured the left side of his face. The siblings proved to be very strong opponents for the demon slayers.

4 Cusack And Chandler From Seven Deadly Sins

Chandler and Cusack from Seven Deadly Sins

Both of them were high-ranked members of the Demon Clan. Cusack trained Zeldris while Chandler trained Meliodas. Both the teachers were extremely loyal to their students and were willing to go to extremes to protect them.

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Originally, Cusack and Chandler were just one demon known as the Original Demon, but after betraying the Demon King, his body was divided into the two demons. Cusack and Chandler could go from calm to berserk in a very short period. Chandler in particular was shown to be extremely ruthless as he was ready to kill anyone who stood between him and Meliodas.

3 Big Mom And Kaido From One Piece

One Piece Kaido and Big Mom partying

Big Mom and Kaido are two of the Yonko. At some point in the past, they were on the same crew, however, after the collapse of the Rocks Pirates, they went their separate ways and started their own pirate crews. However, they allied together during the Wano Country arc, which struck fear into the hearts of the Marines and the World Government.

The two are among the strongest known characters in the series and their combined power is astounding. They fought against the members of the Worst Generation on the rooftop and the Yonko came out on top. Big Mom is known for killing everyone who disobeys her including her children. On the other hand, Kaido is a monster, who single-handedly caused the ruin of Wano.

2 Hisoka And Illumi From Hunter x Hunter

Illumi and Hisoka from Hunter x Hunter

Ever since their first appearance, Hisoka and Illumi came off as a creepy duo. The two of them are malevolent, and they don't hesitate to hurt anyone who stands between their goals.

Unlike most villain duos, Hisoka and Illumi have helped each other. Illumi helped Hisoka to get a chance at fighting the leader of the Phantom Troupe, and Hisoka aided Illumi in his plans to find his brother. However, they also believe that one of them would kill the other, which is why they are on their toes around each other.

1 Kakuzu And Hidan From Naruto

Naruto Hidan and Kakuzu from Akatsuki

Kakuzu and Hidan were members of Akatsuki. They were almost unkillable and because of that they came to be known as the "Zombie Duo." Kakuzu was a ninja who once fought against the legendary Hashirama Senju. Kakuzu was only cared about money, while Hidan was devoted to sacrificing people for the sake of Jashin.

Hidan did not have the intelligence, but his way of killing people was evil. He would take their blood and conduct a ritual and the person would die horribly. Kakuzu was not far off either; he would steal the hearts of powerful opponents to prolong his life and increase his power.

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