A.I.s are some of the most intelligent anime characters who often have fascinating backstories and highly emotional character arcs. Even though these anime characters aren't biological humans their stories still resonated with fans and sparked many conversations about identity and human existence.

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Anime fans could embark on some of the most futuristic and even fantasy-inspired adventures while meeting some of the most hilarious and powerful A.I. characters in anime. Thanks to innovative anime artists, fans could explore thought-provoking stories and meet some of the most complex anime characters of all time. These fun stories are not just for fans who love the best mecha anime shows and series with robots and futuristic tech but for all anime lovers who prefer meaningful entertainment.

7 Isla - Plastic Memories

Isla in Plastic Memories

Plastic Memories has one of the saddest anime romances with bitter endings between a human boy and an A.I. girl. Isla is a sweet android, aka Giftia, who works at SAI Corp, the powerful company that created Giftias. Just like other Giftias Isla not only looks like humans but has the same emotions and memories as well.

Thanks to Plastic Memories and Isla, anime fans can go on an emotional adventure as they follow Tsuakasa's journey after the young boy gets a job at SAI Corp. Tsuakasa has to work at the department where soon-to-be-expiring Giftias are put to rest and that's where he meets Isla. The two soon start developing feelings for each other despite knowing all too well how their relationship will end.

6 Yui - Sword Art Online

Yui in Sword Art Online

While Yui might not be one of the strongest characters in Sword Art Online but she's certainly its cutest one. Even though Yui was an A.I. character who was only developed to help players with their mental health problems and didn't know that she was a sentient A.I. when Asuna and Kirito first met her.

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Yui was a fan-favorite character in Sword Art Online whose heartbreaking story finally became more positive when she got adopted by Kirito and Asuna. Sword Art Online follows the adventures of Kirito and millions of other players who suddenly discover that they are unable to escape a multiplayer virtual-reality game.

5 Arale Norimaki - Dr. Slump

Arale Norimaki in Dr. Slump

Arale Norimaki is one of the most energetic and lovable A.I. characters in anime. She was built by the inventor, Senbei Norimaki, whose original goal was to create the perfect humanoid robot. However, Arale was far from perfect since she was not only nearsighted but had an issue with thinking things true.

She even had to keep her true identity a secret and pretend that she was just a weirdly strong little girl. Dr. Slump is one of the most hilarious underrated anime shows from the 80s with an unforgettable A.I. anime character and laugh-out-loud funny adventures.

4 Doraemon

Doraemon in Doraemon

Doraemon is one of the most popular A.I. characters in anime who was around since the 70s. He's one of the sweetest anime A.I.s who was always ready to help out not only Nobita but all other humans. Doraemon has some really fun and useful gadgets he uses to solve problems.

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While he's an intelligent robot A.I. cat he can also be jealous and is easily annoyed. Doraemon had some of the funniest and sweetest classic anime moments thanks to this iconic anime A.I. character. The anime follows his adventures after Doraemon, who travels back in time from the 22nd century, helps a young boy become the best version of himself.

3 Tama - Gintama

Tama in Gintama

Tama, aka No 0, has one of the saddest backstories in Gintama. She was created by a scientist who wanted to build a robot for his daughter. However, while he was implanting his daughter's personality into Tama he accidentally killed his daughter. Thanks to this process Tama was not only exceptionally strong but became capable of experiencing human emotions too.

Even though Tama is one of the most powerful characters in Gintama she still worked as a maidroid at Otose's Snack House. Tama is one of the sweetest anime A.I.s who just wanted to serve and make humans happy. Gintama follows the hilarious adventures of Gintoki who tries to live a normal life while working odd jobs in a futuristic Japan where aliens and humans live together.

2 Cell - Dragon Ball Z

Cell in Dragon Ball Z

Cell is the scariest A.I. character in anime who was one of Goku's most formidable opponents. Dragon Ball Z's terrifying A.I. was created by Dr. Gero and arrived from a future timeline to absorb human energy as well as Android 17 and 18.

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He was a cunning and merciless warrior with powerful special abilities that made him almost undestroyable. Cell was created to be the perfect weapon and while he would change after each of his transformations he was always concentrating on his ultimate goal. Dragon Ball Z's story follows the adventures of Goku and his friends as the team are trying to defend Earth from deadly villains.

1 Motoko Kusanagi - Ghost In The Shell

Motoko in Ghost In The Shell

Motoko Kusanagi is the single most popular A.I. anime character of all time. Her iconic and thought-provoking story inspired all viewers to think more deeply about humanity's relationship with technology as well as about identity.

This powerful cyborg was a major in her unit and successfully apprehended many dangerous criminals. Motoko was intelligent and strong and while she had friends she always preferred to concentrate on her job. Ghost In The Shell followed Motoko's adventures as she was trying to hunt down a mysterious hacker called the Puppet Master.

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